Temozolomide (NSC 362856), DNA Alkylator
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Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
Temozolomide, CAS# 85622-93-1, 2226
Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?
Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma - ScienceDirect
Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide
Nanomaterials, Free Full-Text
Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide in: Journal of Neurosurgery Volume 99 Issue 6 (2003) Journals
DNA Damage/DNA Repair - BioCrick
Temozolomide (NSC 362856), DNA Alkylator
In search of effective therapies to overcome resistance to Temozolomide in brain tumours
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